What is this stuff. Press question mark to learn the rest of the keyboard shortcuts, https://www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptoms. Depression Success Stories (3 Viewing) 175: 1,337: My recovery from... by boromichael. Treatment Resistant Depression (3 Viewing) For those suffering from … SAMe may not be safe for people with bipolar disorder. Doing a quick lit. It's been a little over two months. S-Adenosyl methionine (SAM-e) is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. best. This supplement is counterindicated for bipolar. Here are some symptoms of under-/over-methylation: https://www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptomsSince you have noticed positive effects from SAM-e, you are probably undermethylated. If low serotonin causes your depression, and the antidepressive helping you is an SSRI, you are probably undermethylated. 1. This thread is archived. Liver disease. L-theanine helps. It is very strong. Depression can cause us to lose sight of ourselves — at least the parts of ourselves that are bright, shiny, and healthy. That bolded text should pretty much be your entire takeaway. I've been eating turkey every night for the past week while I've been trying to get my sleep under control lol, It's hard to tell how I'm doing at a lower dose because there is definitely, 100% withdrawal with this vitamin. Now like all things in life, it's not perfect - since it's a supplement, it's not covered (in north america) by insurance, and perhaps most relevant for us, it has been shown to induce mania at a rate similar to tricyclics. Discussion and anecdotes are welcome! It is also a promising neuroprotectant and may be helpful in treating ADHD. La SAMe et la dépression : une recherche superbe ! In June of 2017, a group of psychiatrists from four Ivy League Medical Schools and other schools as well, evaluated 132 scientific studies that have been done to determine whether or not SAMe is effective in the treatment of several … I was on two pills as of this Monday, and half a pill as of today. That's very smart. This was a number of years ago so I can't recall the dose. 144 is a big enough sample size that I'll take it seriously. That started to wear off after a few more days so I went up to 1200. I would love a natural alternative to continuing to switch pills. Find other natural ways to improve your mood. I know this post is a little old but I still want to put out a warning that Sam-E is addictive and has almost identical withdrawals to SSRI's. SAM-e like St. John’s wort is also very well studied. Hot New Top. When we feel broken, we lose our self-esteem. Low quality posts will be removed. Press J to jump to the feed. We have no clue how often it induces mania in the presence of an anti-manic agent, and we do know some "mood stabilizers" (I hate that term) have been documented to induce mania (you shouldn't have to look further than a google scholar search for "lamotrigine manic switch" or "lurasidone manic switch"), but are more than just used for bipolar but downright approved to treat it by reimbursement agencies. You should however never start with 3x400MG=1200MG. If low serotonin causes your depression, and the antidepressive helping you is an SSRI, you are probably undermethylated. It did nothing for me. r/depression: Peer support for anyone struggling with a depressive disorder. But there are also studies that suggest it may induce mania: A Case Report of a Manic Episode Triggered by S-Adenosylmethionine (SAMe). It did not substitute for grief, she still felt grief (which was fortunate). If you are not and even worse, if you are overmethylated it will cause more problems instead. By raising the levels of dopamine in your brain, SAM-e helps enhance memory, motivation and learning.Researchers at the West Los Angeles VA Medical Center studied the antidepressant eff… no comments yet. But a .74 effect size and a p value better than lexapro (lexapro, right?) I'm also on multiple anti-manic agents and strongly feel you shouldn't add supplements to your medication regimen without your doctor's explicit approval. Here's what's in it: SAM-E (400 MG) Vitamin D (2000 MG) Magnesium Glycinate (250 MG) Tumeric powder (Unsure) Fish powder (Unsure) L-Theanine (Unsure) B6 35MG B12 2000 MCG Folic Acid 1000 MCG This was intended to boost the effects of my anti-depressant and hopefully help reduce my current dose. It has been noticed that decreased levels of the … I just want to try something thatll work in a reasonable timeframe without destroying my memory (ect) or landing me in jail (ketamine). SAM-e provides a source of sulfur, which is a critical … 01-30-2021 09:35 PM. Il semblerait que les personnes ayant un taux trop faible de SAM dans le sang, sont plus sujettes à la dépression, aux troubles articulaires et aux affections chroniques du foie. My own bf stood me up and I posted pics of myself and danced to good music in my house tonight. She had exactly the same results everyone else I knew had with the SAM-E - her debilitating depression was ended and she was able to think and even be cheerful. A case report that tells us about a single individual. Then it just makes me very very anxious and uncomfortable. You should however never start with 3x400MG=1200MG. Research on SAMe use for specific conditions shows: 1. SAME-e is one of the main building blocks your brain needs to produce the neurotransmitters acetylcholine, dopamine, serotonin, norepinephrine and melatonin. I also take Cymbalta 60mg. User account menu /r/depression, because nobody should be alone in a dark place r/ depression. Sam-e helped my treatment-resistant depression. 100% Upvoted. So, paradoxically, it was cheaper for my psychiatrist to try various combinations of prescription medications, all covered by my health insurance, than for … Less evidence supports the use of oral SAM-e, although some trials have demonstrated its efficacy as well. Depression can occur in both men and woman of any age. For this reason, it’s believed that SAM-e supplementation may represent a useful therapy for liver disease . share . There are also other nutrients that could be helpful in addition to SAM-e. Also if you have problems sleeping (like Inositol and Tryptophan). card. While research has shown that SAMe has a positive effect in treating depression, most studies weren't well-designed and included a small number of people. I've stayed there ever since and it's been decent. review there seems, as you've said, to be little in the way of actual research on the treatment. Fish oil: fuck this it's not letting me copy out what I want but this abstract discusses efficacy in the Hamilton Depression Rating Scale of fish oil with a sample size of 12 and no manic switches. Be the first to share what you think! Then there was then a steady decline in my ability to sleep through the night, which of course meant my mood tanked and I then got really snappy. SAMe and Depression. Going from 400mg down to 200mg was no big deal, and so was going down to 100mg. That being said SSRIs don't have fantastic efficacy either. I have a video before this when I first started taking it. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary … I'm also hyper sensitive to anything with caffeine in it now, including chocolate. Sort by. SAM-e for depression. 0 comments. save hide report. I'm down to about 60MG now. But she had a healthy grief, and the deep down depression was no longer a factor. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. Une carence en ces vitamines peut abaisser le taux naturel de SAM dans l'organisme. I cleaned my house. Rising. I would love to take something that cushions the effects of withdrawal (as there are a couple of medications I'd like to come off of). SAM-e is excellent if you are undermethylated. Posted Nov 20, 2018 That stuff is basically legal meth and I expect it to be banned st some point. Thank you :) I'm going to ask my Pdoc about this. A user on Cure Zone said that SAM-E has helped them “almost magically with depression.” This same user said that it is “a … This is just my particular story and I'm just one person, please use caution. From novel/alternative substances, to established medications. Now even as tough as she is, she'll reach for a SAM-E every … I really love the idea of this vitamin because I've had a really tough time with traditional anti-depressants. Sam-E information is available online along with its effects and working pattern on patients. You may even be able to completely wean off them! I have no clue what neurotransmitters it's involved in and it sounds like even sources arguing it works are admitting in no uncertain terms that they aren't sure how it works. If you want OTC supplements that appear to have evidence suggesting safe efficacy for bipolar, please research Omega-3 fish oil supplements and N-Acetyl-Cysteine.source note It's a pain finding sources I don't have at the ready, but there's a lot out there on fish oil and I'd really like you to do the research yourself to come to your decisions from an informed perspective, but the following is a weak source indicating fish oil can be safe and effective in BP. Looking back, that may have been too much for me. Unsafe unless advised by your doctor otherwise. My doc also approved of it cautiously. Even though SAMe is sold without a prescription, you should consult with your doctor about your depression rather than simply try to treat yourself. 11-19-2020 11:30 AM. What dose are you on? The recommended dose is three pills = 400 MG. I´ve been looking to all the threads about this two supplements. Page 1 of 2 - Sam-e or 5-htp for anxiety and depression - posted in Supplements: Hi. Doesn't mean it isn't safe, but you know...why risk it? SAM-e boosts brain health and function in several ways. It's not the most robust source, but there's quite a lot else like it and I recommend taking neither NAC nor fish oil without your doctor okaying it first. I'd been taking it for about 6 years and decided to taper down in the past few months. It's not clear if SAMe is beneficial for people who have liver disease. I felt like I was rapidly circling through manic and depressed episodes throughout the day, going from extremely happy and energetic, have thoughts rush through my head to feeling super bad and … It's an amazing tool and necessity for me. SAM-e is excellent if you are undermethylated. Depression affects people across all ethnic groups and socioeconomic backgrounds. Regards, VITAcure.me, Super helpful, thanks! I don't know if I should give it another month. Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic1 antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). Id like to be clear, im NOT recommending use of this substance!! But I had to take high doses to notice an effect–and I eventually stopped taking it because it was too expensive. Sub-Forums: Depression: Search this Forum : Forum: Threads: Posts: Last Post: Postpartum Depression (2 Viewing) 62: 324: I don't have friends and it... by mountainstream. If you want to chase those initial positive effects, buy each nutrient individually and in smaller doses, and then experiment carefully, adding one at a time. D shouldn't cause anxiety. People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAMe for their depressive symptoms except under the supervision of a health care provider because SAMe may worsen symptoms of mania. In numerous high-quality studies, it's been shown to be just as effective (if not more) as tricyclics, while kicking into effect much faster (1-2 weeks instead of 6 weeks). But, working on the monoamine hypothesis, it could make sense that there be a link between this here treatment (which, I think, is to increase the bioavalibility of the precursers to the monoamines) and an … Source note: yes, that's a blog and not a scholarly source, but it does list quite a number of legitimate sources and it's easier to share a bibliography with great sources than to list them individually. Definitely less anxious. And accordingly, we may hate ourselves for feelings we have little control over. If I remember correctly, my dosage of SAM-E varied from 800mg to 1600mg. Other uses of SAM-e have not been studied as thoroughly. 3. I'm saying this is absolutely something not to take without your doctor okaying it. Some studies have found that SAM-e might work as well as tricyclic antidepressants in relieving symptoms. Sam-e is an incredibly dangerous medication and cost me my job. People assume that having depression just means you’re sad all the time. And make sure you know if stuff is with food or not (I know obvious). Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pubmed/19909689. But two in particular stand out. Important Sam-E information. I always try things separate first. Read user ratings and reviews for SAMe on WebMD including side effects and interactions, treatment effectiveness, ease of use, safety and satisfaction. Additionally, it's uncommon for either class to be Rx'd to us. When did you notice things becoming different? And in these studies, SAM-e has been administered orally, intramuscularly or intravenously and doses have ranged from 200 to 1600 mg a day and more recently doses even as high as 3200 mg a day. SSRIs S-adenosyl-methionine (SAMe) for Depressed Mood SAMe is safe and can help treat depressed mood, research finds. One Reddit user even called it the “happy plant,” saying that it made him more socially outgoing and ... SAM-e is an essential amino acid which has been used to reverse neurodegenerative diseases, promote memory, improve mood and fight depression. Latuda showed me what being normal could be like, then it took it away in a cruel twist of fate. 5 comments. anyone have any experiences with this? studies that suggest the effectiveness of sam-e: [Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.] it's already used by doctors for depression. This sub is not for venting or for facebook style posts. Many studies comparing the use of SAMe with nonsteroidal anti-inflammatory drugs showed that each provided similar pain relief and improve… But id just like to know if any of you have any experiences with this. Headaches, bloated and upset stomach, achiness, horrible anxiety, insomnia, and tons of other stuff. Press question mark to learn the rest of the keyboard shortcuts . At the time, various folks online (on other messageboards) kept saying that SAM-E does nothing unless you take at least 800mg. I started taking Sam-e about two months ago after months of depression and my doctor not seeming to take it seriously. There's some evidence that SAM-e might help ease the pain of fibromyalgia and spinal cord damage caused by HIV. So I started seeing a psychiatrist who formulated her own "mood boosting" vitamin. The study replaced the SSRI medication with 1600 milligrams of SAM-e per day and measured the effects on depression … After years of investigating SAM-e, Dr. Richard Brown and colleagues at Columbia University have concluded that SAM-e is safe, virtually free of … This is my log overdue update on taking Sam-e to help depression and mood. The people suffering from depression symptoms can take Sam-E for minimum of two weeks to maximum of six weeks depending on the intensity of depression. SAM-e helps alleviate depression. 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Not playing pharmacist on my own bf stood me up and I woke up feeling not depressed which super... Take it seriously take without your doctor okaying it sad all the time, various folks (... Okaying it and anxiety as you are not and even worse, if you are probably.. And anxiety my comment to get so much you can try without cutting out your medications. Mania but absolutely nothing about how often being normal could be like, then it took it this weekend everything!