The pharmacology of CBD is still being investigated. Oral applications include the treatment of sweats in wasting conditions (agaricin has a powerful anhidrotic or antihydrotic effect) or treatment of hyperhydrosis (parasympatholytic or anticholinergic effect), treatment of consumption (tuberculosis), coughing illnesses, feverish illnesses and asthma and use as an emetic, purgative or laxative and use as a parasympatholytic (anticholinergic) agent. In addition, the compounds disclosed herein may be resident ingredients within well-known foods, which, when isolated and concentrated can function as drugs. It is not often that you have absolute consensus between 1,000's of years of herbal practice and every scientific study ever published on that same subject, but that is the case with medicinal mushrooms. Delivery systems include but are not limited to sprays, capsules, tablets, elixirs, emulsions, lozenges, suspensions, syrups, pills, lotions, epidermal patches, suppositories, inhalers and injectables, or by other means known to the art of drug delivery. It is therefore possible that the Selectivity Index ratios may be understated, as SI is the CC50 (cytotoxicity) divided by EC (effective concentration) (the amount that will kill 50% of the human cells divided by the amount to kill 50% of the virus). The net total overall viral pathogen particle counts of bees receiving mycelium extracts in their sugar water at 0.1% and 1%, showed a dose-dependent reduction in overall bee viruses after one week of treatment. 14/641,432: “Integrative fungal solutions for protecting bees” filed Mar. LEM, PSP and PSK are isolated using hot water as the primary, “first step” extracting solvent. Since up to 95% of vanillin is metabolized within the human body into vanillic acid, vanillin and its enzymatically converted analogs, are also predicted to be primary antiviral agents against viruses, particularly against herpes viruses related to varicella zoster viruses. These compounds may be the first among many showing dual activity against these two disparate categories of infectious agents. The effect of the antiviral and antibacterial components within the aforementioned mushroom species and their relatives may be the decisive factor that improves survivability from infection in many animals including humans, dogs, cats, horses, cows, pigs, birds, fish, insects (including bees) and other wild and domesticated animals. All the above five mentioned molecules selected and submitted on behalf of the inventor greatly exceeded cidofovir's anti-HPV activity. Five weeks after beginning these alternative approaches, a MRI revealed complete remission of his liver metastasis, and he has remained asymptomatic for a total of 53 months, with the most recent scan showing no evidence of disease. When immunity is lowered, the human body is less able to eradicate cancer cells, which would otherwise be kept in check, and deleterious inflammatory pathways further challenge health. ), Reishi (Ganoderma lucidum s.l. is commonly known as the Birch Polypore or Kanbatake. Viral counts were conducted using assays described in U.S. patent application Ser. These compounds may directly, or indirectly, positively influence disease outcomes, as they work via separate pathways and activate sets of receptors, which cumulatively and synergistically enhance immunity, overcome toxicity of xenobiotic toxins, have antiviral and antibacterial properties and potentiate benefits from other drug therapies. The tissue is then trypsinized using trypsin at 0.25% with continuous stirring for 15 min at 37° C. in a CO2 incubator. 7, 2014 (currently co-pending), application Ser. 7, p. 495-506 ・P. Scientists have extensively studied extracts of the fruitbodies over the past decades. However, 700-880 mg of vanillin is within the therapeutic dosage window to impart antiviral effects for a 70-88 kg person. Another mushroom recognized for its antiviral activity is Fomes fomentarius, a hoof-shaped wood conk growing trees, which inhibited the tobacco mosaic virus (Aoki et al., 1993). Although numerous papers have been published showing hot water extracts of mushrooms and their mycelia can activate immune systems and can be anti-inflammatory, comparatively few have elucidated the benefits of the alcohol fractions. 1, 2014), which is a continuation-in-part of U.S. application Ser. The risk of death from influenza is highest among persons aged 65 or older, although young children, particularly the newborn, and persons with certain chronic conditions are also at risk of death. GLMe-1, -2, -4 and -7 isolated from the MeOH fraction exhibited inhibitory effects, especially on the cytopathic effects induced by VSV Indiana and New Jersey strains at concentrations which did not show cytotoxicity against Vero cells; however, they exhibited no effect on the other viruses such as HSV and influenza A virus.”. Orthopox (orthopoxviruses or poxviruses) includes the virus that causes smallpox (Variola). 14/641,432: “Integrative fungal solutions for protecting bees,” 2015.). The applicant anticipates that since DNA techniques and other advances in taxonomy will likely result in changes in names, the splitting of species, and even in the transfer of species to other genera, that the Polyporaceae species mentioned in this patent application are those as understood by the most complete monograph on the subject, Ryvarden & Gilbertson's North American Polypores, 1986 vol. Other Category A agents are anthrax, plague, botulism, tularemia, and viral hemorrhagic fevers. Few effective antiviral drugs have been discovered. The difference here then between a food and a drug is that a drug is typically an isolated molecule presented in a form at a high purity (i.e. of fresh mycelium on rice for every 3000 ml. adult, (extracts of individual fungal species and/or combinations of species) are preferably 0.1-20 g/day, more preferably 0.25-10 g/day, and most preferably 0.5-5 g/day. Incubation times are preferably 7-180 days, more preferably 30-120 days. The mechanism of SARS pathogenesis may involve both direct viral cytocidal effects on the target cells and immune-mediated mechanisms. BOX 7634, Olympia, Wash. 98507) has been attributed by several customers to alleviate Lyme disease symptoms. No. ・P. This amount may vary to some degree depending on the mode of administration, but will be in the same general range. No. The EC50 values are determined by comparing drug treated and untreated cells using a computer program. It is found throughout the birch forests of the world, circumboreal, and is one of the most common mushrooms on that host. This gives final drug concentrations beginning with 100 μg/ml and ending with 0.03 μg/ml and a final agarose overlay concentration of 0.5%. The dissociated fragmented mycelial mass allows for a multiple loci inoculation, resulting in accelerated colonization and allowing for the ease of further dilutions and inoculations. Provisional Application No. resinaceum (“G.r.”) blends, compositions consisting of 5-95% G.r. 8,765,138, issued Jul. From the more than 200 samples the inventor provided to BioShield, 2,392 antiviral assays were performed on behalf of the inventor; 1,042 of which were influenza tests. All rights reserved. Paul Stamets Quote: “Agarikon contains antiviral molecules new to science. Mizuno et al. These antiviral components are produced by many polypore fungi (polyporales) such as but not limited to Fomitopsis officinalis, Fomitopsis pinicola, Fomes fomentarius, Inonotus obliquus, Ganoderma applanatum, Ganoderma oregonense, Ganoderma resinaceum, Ganoderma sinense, Ganoderma tsugae, Irpex lacteus, Schizophyllum commune, Trametes versicolor and gilled fungi (Agaricales) such as Pleurotus ostreatus, Pleurotus pulmonarius, Pleurotus populinus, Stropharia rugoso-annulata, Stropharia semigloboides, Stropharia ambigua, Psilocybe allenii, Psilocybe azurescens, Psilocybe coprophila, Psilocybe cubensis, Psilocybe cyanescens, Clitocybe odora, and Lactarius fragilis. Provisional Application No. Such forms may have the additional advantages of functioning as antibacterials, antiprotozoals, immunomodulators, nutraceuticals and/or prebiotics as well as enhancing innate immunity defense mechanisms and host immune response, resulting in healing. Additional species likely to provide a reservoir of antiviral molecules include but are not limited to Polyporales and Hymenochaetales such as Antrodia cinnomonea, Fomitiporia robusta, Fomes fomentarius, Ganoderma curtisii, Ganoderma lingzhi, Grifola frondosa, Heterobasidion annosum, Inonotus hispidus, Inonotus andersonii, Inonotus dryadeus, Irpex lacteus, Laetiporus cincinnatus, Laetiporus sulphureus, Laetiporus conifericola, Lentinula edodes, Lenzites betulina, Phanerochaete chrysosporium, Phaeolus schweinitzii, Phellinus baumii, Phellinus igniarius, Phellinus linteus, Phellinus pini, Polyporus elegans, Phanerochaetes chrysosporium, Phaeolus schweitnitzii, Stereum complicatum, Stereum hirsutum, Stereum ostrea, Trametes elegans, Trametes gibbosa, Trametes hirsuta, Trametes villosa, Trametes cingulata, Trametes ochracea, Trametes pubescens, Trametes ectypa, Trametes aesculi, Wolfiporia cocos, and Agaricales such as Agaricus augustus, Agaricus blazei, Agaricus bonardii, Agaricus brasiliensis, Agaricus campestris, Agaricus lilaceps, Agaricus placomyces, Agaricus subrufescens, Agaricus sylvicola, Agrocybe pediades, Agrocybe aegerita, Agrocybe arvalis, Agrocybe praecox, Amanita muscaria, Amanita gemmata, Amanita pantherina, Amanita phalloides, Amanita virosa, Amanita pachycolea, Amanita vaginata, Clitocybe odora, Clitocybe dealbata, Clitocybe dilitata, Conocybe cyanopus, Conocybe lacteus, Conocybe rickenii, Conocybe smithii, Conocybe tenera, Coprinopsis atrementaria, Coprinopsis nivea, Coprinopsis lagopus, Coprinus comatus, Coprinus micaceus, Galerina autumnalis, Galerina marginata, Galerina venenata, Gymnopus hydrophilus, Gymnopilus peronatus, Hypholoma aurantica (Leratiomyces ceres), Hypholoma capnoides, Hypholoma fasciculare, Hypholoma sublateritium, Hypsizygus marmoreus, Hypsizygus tessulatus, Hypsizygus ulmarius, Lentinus ponderosus, Lepiota procera (Macrolepiota procera), Lepiota rachodes (Chlorophyllum rachodes), Lepista nuda, Mycena alcalina, Mycena pura, Mycena aurantiadisca, Panellus serotinus, Panaeolus foenisecii, Panaeolus subbalteatus, Pleurotus columbinus, Pleurotus ostreatus, Pleurotus cystidiosus, Pleurotus pulmonarius, Pleurotus sapidus, Pleurotus tuberregium, Panellus stipticus, Panellus serotinus, Pluteus cervinus, Psathyrella aquatica, Psathyrella condolleana, Psathyrella hydrophila, Psilocybe allenii, Psilocybe azurescens, Psilocybe baeocystis, Psilocybe caerulescens, Psilocybe coprophila, Psilocybe cubensis, Psilocybe cyanescens, Psilocybe ovoideocystidiata, Psilocybe semilanceata, Psilocybe stuntzii, Psilocybe subaeruginosa, Psilocybe weilii, Stropharia aeruginosa, Stropharia coronilla, Stropharia coronilla, Stropharia cyanea, Stropharia rugoso-annulata, Stropharia semiglobata, Stropharia semigloboides, Stropharia squamosa, Stropharia thrausta, Stropharia umbonotescens, Termitomyces robusta, Volvaria bombycina, Volvariella volvacea, and ascomycetes such as Metarhizium anisopliae, Metarhizium acridum, Beauveria bassiana, Cordyceps capitata, Cordyceps militaris, Cordyceps sinensis sensu lato, Cordyceps subsessilis, Ophiocordyceps sinensis, and Ophiocordyceps unilateralis. 7634, Olympia, Wash. 98507 ) has been isolated from bats ) serves..., grown or fermented on solid, semi-solid or liquid media do these extracts purified... 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